Popular Science Lecture - 64

Nobel Prize in Physiology or Medicine 2023
mRNA vaccines - a new era in vaccinology


Venue: Anna Centenary Library,
Kotturpuram
Chennai

October 28, 2023
4:00 pm - 6:00 pm
Organised by Tamil Nadu Science Forum

About Program







This is part of its efforts to popularize science to the general public and students who are pursuing science as their career. TNSF attempt to focus on students on higher science as everyone knows that learning of science at college within the curriculum is not enough to acquire holistic knowledge of science at the appropriate time. Hence, to fill the gap between what students are acquiring through the curriculum and what it is required, TNSF is planning its activities on higher science to students who are pursuing higher education.



About the Lecture
In our cells, genetic information encoded in DNA is transferred to messenger RNA (mRNA), which is used as a template for protein production. During the 1980s, efficient methods for producing mRNA without cell culture were introduced, called in vitro transcription. This decisive step accelerated the development of molecular biology applications in several fields. Ideas of using mRNA technologies for vaccine and therapeutic purposes also took off, but roadblocks lay ahead. Karikó and Weissman noticed that dendritic cells recognize in vitro transcribed mRNA as a foreign substance, which leads to their activation and the release of inflammatory signaling molecules. They produced different variants of mRNA, each with unique chemical alterations in their bases, which they delivered to dendritic cells. The results were striking: The inflammatory response was almost abolished when base modifications were included in the mRNA. This was a paradigm change in our understanding of how cells recognize and respond to different forms of mRNA. Karikó and Weissman immediately understood that their discovery had profound significance for using mRNA as therapy. These seminal results were published in 2005.

கோவிட்-19 க்கு எதிராக பயனுள்ள எம்ஆர்என்ஏ தடுப்பூசிகளை உருவாக்க உதவிய நியூக்ளியோசைட் அடிப்படை மாற்றங்கள் தொடர்பான கண்டுபிடிப்புகளுக்காக வழங்கப்பட்டுள்ளது

SCHEDULE

Time: 4:00 pm to 6:00 pm - October 28, 2023

Attendenace Registration starts at 03:30 pm

4:00 pm

Introduction

4:10 pm

DR. LUKE ELIZABETH HANNA
Scientist F, National Institute for Research in Tuberculosis, Chennai

mRNA vaccines - a new era in vaccinology

5:00 pm

Q & A

Speakers

DR. LUKE ELIZABETH HANNA

DR. LUKE ELIZABETH HANNA

DR. LUKE ELIZABETH HANNA has a background in Immunology with more than 20 years of working experience in the broad area of immunopathogenesis of infectious diseases and have undertaken a number of research studies on host immune responses to pulmonary and extrapulmonary tuberculosis, HIV infection and HIV/TB coinfection. She has also been trained in molecular virology of HIV.
She has been actively involved in research aimed at understanding the host immune response to TB, and TB with HIV and helminth co-infections, and identification of biomarkers for disease progression and treatment response. The other aspect of her study focuses on characterizing the unique features of HIV1 subtype C isolates circulating in the Indian population. Some interesting observations have been made in this line and they have resulted in some recent publications. She has also been involved in the design and development of some clinically and scientifically relevant databases such as TB Drugs, Mycobacterium tuberculosis Structure Data base (MtbSD) and Database of drug targets for resistant pathogens (DDTRP).

Venue

Anna Centenary Library
Kotturpuram
Chennai

Call

+91 9176512565

Email us

tamilnadutnsfchennai@gmail.com

Past Events

Nobel Prize 2018 - [Physics] and Special Report on Global Warming of 1.5ºC by IPCC
Talk on Raman Effect & Emergence
Talk on Climate Change
LHC and Detection of Higgs Boson
Evolution And Datura - பரிணாம வளர்ச்சியும் ஊமத்தையும்
Science for Peace
Data Science, Artificial Intelligence and Cryptography
Biodiversity in Western Ghats
Nobel Prize 2019 - Physiology and Medicine
Nobel Prize 2019 - Physics
Nobel Prize 2019 - Chemistry
Evidence from a neuroimaging study of Sports
The cryosphere and climate of the earth
Demystifying Coronavirus
The discovery of Hepatitis C virus
The black hole formation and the centre of our galaxy
Genome Editing
From “you and your brain” to “you vs. your brain”
Status of COVID-19 Vaccines
Art and Metal Technology of Chola Bronzes
Himalayan Glaciers - Science & Facts
Covid-19: Created or evolved?
செயற்கை நுண்ணறிவு: வாய்ப்புகளும், சவால்களும்
Next-Generation DNA Sequencing Technologies
Dark Matter and its Detection
Steven Weinberg: The physicist and his physics
The Nobel Prize in Physics 2021
The Nobel Prize in Physiology or Medicine 2021
The Nobel Prize in Chemistry 2021
Science, Equity, and Climate Action at COP-26
A-Satyameva Jayate in Post-Truth India
Unraveling the universe with James Webb Space Telescope
Invisible Empire: How viruses and microbes shape our world
COULD WE BUILD A MINIATURE SUN ON EARTH?
The Story of our Star, the Sun
To be or knot to be
Evolution of Parental Care in frogs and toads
Quantum Entanglement
Genome Sequencing of the Extinct
The Nobel Prize in Chemistry 2022 - Click Chemistry
The 36 officers of Euler: From puzzle to quantum physics
Chemistry through Experiments
Gene Editing-based Novel therapeutics
PSL 58 - Darwin Day Special Lecture
PSL 59 - Masala Lab: The Science of Indian Cooking
PSL 60 -Academic Intelligence
PSL 61 -Exciting Development in exploring Gravitational Waves
PSL 62 - Our Wondrous and Complex World
PSL 63 - Nobel Prize in Chemistry 2023 - Discovery and Development of Quantum Dots