Popular Science Lecture - 74

Covid Vaccines: Good, Bad and Ugly - An Immunologist Perspective


Venue: Anna Centenary Library
Kotturpuram
Chennai

June 15, 2024
11:00 am - 1:00 pm
Organised by Anna Centenary Library, Chennai & TNSF

About Program







This is part of its efforts to popularize science to the general public and students who are pursuing science as their career. TNSF attempt to focus on students on higher science as everyone knows that learning of science at college within the curriculum is not enough to acquire holistic knowledge of science at the appropriate time. Hence, to fill the gap between what students are acquiring through the curriculum and what it is required, TNSF is planning its activities on higher science to students who are pursuing higher education.


About the Lecture
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was an unprecedented global calamity. Covid vaccine was a global emergency. Vaccination programmes were rolled out globally, and most of these vaccines were approved without extensive clinical studies on their side-effects and efficacy. Vaccines like drugs also have side effects: some are acute and some are chronic. Acute side effects (Less than 6 months) are easy to detect and can be evaluated but chronic side effects (>6 months) are much more difficult to detect and prove. Vaccine while imparting immunity, can also induce inflammation, which is seldom studied. Again vaccine induced inflammation can either be acute or chronic. Chronic inflammation can lead to metabolic disturbances (metainflammation). The concept of metainflammation is relatively new, but real. These metabolic disturbances can range anywhere from insulin resistance (which can lead to diabetes) to thrombosis (which can lead to stroke or heart attack). While the antigens in the vaccine induces immunity, the adjuvants which are incorporated to enhance vaccine efficacy, can cause inflammation. Does this mean that, people shouldn't have taken the vaccine or the manufacturers have ended up producing a goofed-up product? The answer is a big NO. Covid vaccines (covishield or covaccine) were largely effective in curtailing the disease, BUT there is a possibility that they might have induced metainflammation. Having said that, what should be the next move? The answer is twofold: At the individual level and at the societal level. At the individual level, vaccinated individuals can undergo screening for common risk factors for metabolic diseases like blood glucose, hypertension, lipid profile, CRP, D-dimers etc. A simple ECG test might also help. At the societal level, Govt should conduct large scale epidemiological studies to access metabolic risk factors, among vaccinated individuals and also to identify immune biomarkers which can be used to identity high risk individuals for vaccine induced metabolic derailment. Scientists should also start working on nutraceuticals which can reduce metainflammation, which can be given as food supplements to reduce inflammation.

SARS-CoV-2 ஆல் ஏற்பட்ட கோவிட்-19 தொற்றுநோய் உலகளாவிய பேரழிவாகும். இதை எதிர்கொள்ளும் விதமாக, கோவிட்-19 தடுப்பூசிகள் வேகமாக உருவாக்கப்பட்டன. பெரும்பாலும் அவற்றின் பக்க விளைவுகள் மற்றும் செயல்திறன் பற்றிய விரிவான மருத்துவ ஆய்வுகள் இல்லாமல் உலகம் முழுவதும் பயன்படுத்தப்பட்டன. மருந்துகளுக்கிருப்பது போல் தடுப்பூசிகளுக்கும் குறுகிய கால பக்க விளைவுகளும் (6 மாதங்களுக்கும் குறைவாக) அல்லது நீண்டகால பக்கவிளைவுகளும் (6 மாதங்களுக்கு மேல்) உள்ளன. குறுகியகால பக்க விளைவுகளை கண்டறிவது எளிது. ஆனால் நீண்டகாலப் பக்க விளைவுகள் அடையாளம் காண்பது மிகவும் சவாலானது. நோய் எதிர்ப்பு சக்தி மற்றும் அழற்சி ஆகிய இரண்டையும் தடுப்பூசிகள் தூண்டலாம், பிந்தையது அரிதாகவே ஆய்வு செய்யப்படுகிறது.அது குறுகிய காலமானதாக அல்லது நீண்டகாலமானதாக இருக்கலாம். நீண்டகால அழற்சி அல்லது மெட்டா அழற்சி என்பது ஒரு புதிய ஆனால் உண்மையான கருத்தாகும், இது இன்சுலின் எதிர்ப்பு (நீரிழிவு நோய்க்கு வழிவகுக்கும்) மற்றும் த்ரோம்போசிஸ் (பக்கவாதம் அல்லது மாரடைப்புக்கு வழிவகுக்கும்) போன்ற வளர்சிதை மாற்றக் கோளாறுகளுக்கு வழிவகுக்கும். தடுப்பூசிகளில் உள்ள துணை மருந்துகள் , அவற்றின் செயல்திறனை அதிகரிக்கின்றன, அவையும் அழற்சியை ஏற்படுத்தும். இந்த சாத்தியமான சிக்கல்கள் இருந்தபோதிலும், கோவிஷீல்ட் மற்றும் கோவாக்சின் போன்ற கோவிட்-19 தடுப்பூசிகள் நோயைக் கட்டுப்படுத்துவதில் பயனுள்ளதாக இருந்தன. இப்போது செய்ய வேண்டியது, தனிநபர்களுக்கு வளர்சிதை மாற்ற நோய் வருவதற்கான ஆபத்தை கண்டறிவதற்காக தனிநபர்களைப் பரிசோதிப்பதாகும். மேலும் நோய் வருவதற்கான அதிகமாக ஆபத்தை சந்திக்கும் நபர்கள் மற்றும் நோயெதிர்ப்பு பையோமார்க்கர்களை அடையாளம் காண அரசாங்கங்கள் பெரிய அளவிலான தொற்றுநோயியல் ஆய்வுகளை நடத்த வேண்டும். கூடுதலாக, மெட்டா அழற்சிகளை குறைக்க வல்ல மருந்துகளாகப் பயன்படும் ஊட்டச்சத்து உணவுப் பொருட்களை விஞ்ஞானிகள் உருவாக்க வேண்டும்.

SCHEDULE

Time: 11:00 am to 1:00 pm - June 15, 2024

Attendenace Registration starts at 10:30 am

11:00 am

Introduction

11:10 am

Dr.V.Aravindhan
Assistant Professor, Dept of Genetics, Dr ALM PG IBMS, University of Madras

Covid Vaccines: Good, Bad and Ugly- An Immunologist Perspective

12:10 pm

Q & A

Speakers

Dr.V.Aravindhan

Dr.V.Aravindhan

Dr.V.Aravindhan, is an Assitant Professor in the Department of Genetics at Madras University did his Ph.D. in Molecular Biology and Vaccine Research. He moved to the USA for his Post-doctoral research work and joined with Food and Drug Administration. He later moved to National Cancer Institute at Fredrick in the USA. He moved back to India and take up the Scientist position in Dept of Transcriptomics and Molecular Immunology, at Madras Diabetes Research Foundation. He later joined Anna University as a Scientist, Laboratory of Molecular Immunology, Life Sciences, AU-KBC, Anna University, MIT campus before taking up a teaching position at Madras University. He has published more than 35 papers.

Venue

5th Floor, Anna Centenary Library,
Kotturpuram
Chennai

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+91 9176512565

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tamilnadutnsfchennai@gmail.com

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