Popular Science Lecture - 83

Keeping the clock ticking - Daily rhythms of our body in health and disease


Venue: Anna Centenary Library,
Kotturpuram
Chennai

October 26, 2024
11:00 am - 1:00 pm
Organised by Anna Centenary Library & TNSF

About Program







This is part of its efforts to popularize science to the general public and students who are pursuing science as their career. TNSF attempt to focus on students on higher science as everyone knows that learning of science at college within the curriculum is not enough to acquire holistic knowledge of science at the appropriate time. Hence, to fill the gap between what students are acquiring through the curriculum and what it is required, TNSF is planning its activities on higher science to students who are pursuing higher education.



About the Lecture
Our bodies work like clockwork most of the time, to such an extent that we often take our rhythmic behavioral patterns for granted. Our daily ablutions, our sleep-wake cycle, and many other physiological processes have a 24-hour cycle. When these processes get disrupted, for example after a long trans-Atlantic flight, we are well aware of the ensuing few days of ill health. But how do our bodies know how to keep sync with the changing day and night cycle outside? Do the cells in our tissues have a clock that keeps ticking and keeping time? And why does this clock go haphazard when we take a long flight? In this talk, I will give a historical overview of how this clock was first discovered in plants, and then explain the groundbreaking work that went into identifying how exactly this clock functions, leading to the 2017 Nobel Prize in Medicine. Finally, I will end with a brief description of how modern imaging methods combined with advanced machine learning techniques are increasingly allowing measurements and characterization of the body clock in diseases like cancer and neurodegenerative disorders.

எல்லாத் நேரத்திலும் நம் உடல்கள் ஒரு கடிகாரம் போல வேலை செய்கின்றன, அதனால் நம் நாளாந்த நடத்தைச் சுழற்சிகளை நாம் பெரும்பாலும் கவனிக்காமல் கடந்து விடுகிறோம். நமது அன்றாட பழக்கவழக்கங்கள், தூக்க விழிப்பு சுழற்சி மற்றும் பிற உடல் செயல்பாடுகள் 24 மணி நேர சுழற்சியைப் பின்பற்றுகின்றன. இந்த செயல்முறைகள் பாதிக்கப்படும்போது, எடுத்துக்காட்டாக, ஒரு நீண்ட அஞ்சல் விமானப் பயணத்திற்குப் பிறகு, நமக்கு சில நாட்கள் உடல்நல குறைவாக உணர்வு வரும். ஆனால் நம் உடல்கள் வெளியிலிருந்து மாற்றம் ஏற்படும் பகல் மற்றும் இரவு சுழற்சிகளுக்கு எவ்வாறு ஒத்திசைவாக இயங்குகின்றன? எங்கள் திசுக்களில் உள்ள செல்களுக்கு நேரம் நிர்ணயிக்கும் கடிகாரம் இருக்கிறதா? மேலும், நீண்ட பயணம் செய்தால் அந்தக் கடிகாரம் ஏன் குழப்பமாகிறது?
இந்த உரையில், முதலில் இந்தக் கடிகாரம் தாவரங்களில் எவ்வாறு கண்டறியப்பட்டது என்பதை வரலாற்று ரீதியாக விளக்கி, பிறகு இந்தக் கடிகாரம் எவ்வாறு செயல்படுகிறது என்பதற்கான மைல்கல்லாக அமைந்த ஆராய்ச்சியை விளக்குவேன், இது 2017ல் மருத்துவத்திற்கான நோபல் பரிசை வென்றது. இறுதியாக, நவீன படங்களின் முறை combined advanced machine learning தொழில்நுட்பங்களின் உதவியுடன், புற்றுநோய் மற்றும் நரம்பியல் செயலிழப்புக் கோளாறுகள் போன்ற நோய்களில் உடலின் கடிகாரத்தை அளவிடுவது மற்றும் குணமடைப்பது எப்படி என்று விளக்குவேன்.

SCHEDULE

Time: 11:00 am to 1:00 pm - October 26, 2024

Attendance Registration starts at 10:30 am

11:00 am

Introduction

11:10 am

Dr. Shaon Chakrabarti
Faculty, Simon’s Centre, The National Centre for Biological Sciences, Bangaluru

Keeping the clock ticking – daily rhythms of our body in health and disease

12:10 pm

Q & A

Speakers

Shaon

Dr. Shaon Chakrabarti

Dr. Shaon Chakrabarti completed a PhD in Biophysics at the University of Maryland, College Park, where he developed theoretical models to understand the force response of molecular motors and protein-ligand complexes. He then moved to a post-doc position at Harvard University and Dana-Farber Cancer institute, to work on evolutionary modeling of cancer and cancer treatment strategies. Eventually, Shaon started working on experimental cell biology. Currently he is a faculty at the Simon’s Centre at NCBS, where his lab combines theory, Machine Learning and experiments to answer fundamental questions on cell proliferation, circadian clocks and drug resistance in cancer.

Venue

Anna Centenary Library,
Kotturpuram,
Chennai

Call

+91 9176512565

Email us

tamilnadutnsfchennai@gmail.com

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