This is part of its efforts to popularize science to the general public and students who are pursuing science as their career. TNSF attempt to focus on students on higher science as everyone knows that learning of science at college within the curriculum is not enough to acquire holistic knowledge of science at the appropriate time. Hence, to fill the gap between what students are acquiring through the curriculum and what it is required, TNSF is planning its activities on higher science to students who are pursuing higher education.
About the Lecture Proteins perform several functions in living organisms as enzymes, transporters, receptors, antibodies and others. These functions are mainly dictated by their structures. Deciphering the three-dimensional structure of a protein from its amino acid sequence, known as protein folding problem, is a challenging task in structural and computational biology. In this talk, I will briefly introduce the fundamental concepts of protein structure and function along with recent developments and achievements for predicting protein 3D structures, which led to the recognition of a Nobel prize. Further, other equally important tasks such as understanding the stability of protein structures and protein folding rates will be discussed. These aspects are integrated for designing proteins successfully with potential applications, which brought for a reward of a Nobel prize. In addition, various computational resources such as databases and tools available for predicting protein structures, stability, folding rates, binding affinity and design will be highlighted.
Introduction
Prof. M. Michael Gromiha
Department of Biotechnology, Indian Institute of Technology Madras, Chennai
Protein folding puzzle: integrating structure prediction, thermodynamics, kinetics and design
Q & A
Prof. M. Michael Gromiha received his Ph.D. from Bharathidasan University, India. He carried out his postdoctorate at the International Center for Genetic Engineering and Biotechnology (ICGEB), Italy and The Institute of Physical and Chemical Research (RIKEN), Japan. He also served as a Research Scientist and a Senior Research Scientist at Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Japan.