Popular Science Lecture - 84

Protein folding puzzle: integrating structure prediction, thermodynamics, kinetics and design


Venue: Anna Centenary Library,
Kotturpuram
Chennai

November 02, 2024
11:00 am - 1:00 pm
Organised by Anna Centenary Library & TNSF

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About Program







This is part of its efforts to popularize science to the general public and students who are pursuing science as their career. TNSF attempt to focus on students on higher science as everyone knows that learning of science at college within the curriculum is not enough to acquire holistic knowledge of science at the appropriate time. Hence, to fill the gap between what students are acquiring through the curriculum and what it is required, TNSF is planning its activities on higher science to students who are pursuing higher education.



About the Lecture
Proteins perform several functions in living organisms as enzymes, transporters, receptors, antibodies and others. These functions are mainly dictated by their structures. Deciphering the three-dimensional structure of a protein from its amino acid sequence, known as protein folding problem, is a challenging task in structural and computational biology. In this talk, I will briefly introduce the fundamental concepts of protein structure and function along with recent developments and achievements for predicting protein 3D structures, which led to the recognition of a Nobel prize. Further, other equally important tasks such as understanding the stability of protein structures and protein folding rates will be discussed. These aspects are integrated for designing proteins successfully with potential applications, which brought for a reward of a Nobel prize. In addition, various computational resources such as databases and tools available for predicting protein structures, stability, folding rates, binding affinity and design will be highlighted.

உயிரினங்களில் புரதங்கள் பல பாங்கான செயல்களை செய்கின்றன, இவை என்சைம்கள், போக்குவரத்து, ரிசெப்டர்கள், ஆக்டிபாடிகள் ஆகியவையாகும். இந்த செயல்பாடுகள் அடிப்படையாக புரதங்களின் அமைப்பினால் நிர்ணயிக்கப்படுகின்றன. அமினோ அமில வரிசையிலிருந்து புரதத்தின் மூன்று பரிமாண அமைப்பை கண்டு பிடிப்பது மிகப்பெரிய சவாலாகும். நோபல் பரிசு பெற்ற முக்கிய முன்னேற்றங்கள் மற்றும் கணினி கருவிகள், புரத வடிவமைப்பு, நிலைத்தன்மை ஆகியவை குறித்த விவரங்களும் இதில் அடங்கும்.

SCHEDULE

Time: 11:00 am to 1:00 pm - November 2, 2024

Attendance Registration starts at 10:30 am

11:00 am

Introduction

11:10 am

Prof. M. Michael Gromiha
Department of Biotechnology, Indian Institute of Technology Madras, Chennai

Protein folding puzzle: integrating structure prediction, thermodynamics, kinetics and design

12:10 pm

Q & A

Speakers

Prof. M. Michael Gromiha

Prof. M. Michael Gromiha

Prof. M. Michael Gromiha received his Ph.D. from Bharathidasan University, India. He carried out his postdoctorate at the International Center for Genetic Engineering and Biotechnology (ICGEB), Italy and The Institute of Physical and Chemical Research (RIKEN), Japan. He also served as a Research Scientist and a Senior Research Scientist at Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Japan.

Venue

Anna Centenary Library,
Kotturpuram,
Chennai

Call

+91 9176512565

Email us

tamilnadutnsfchennai@gmail.com

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